The University of California, San Diego (UCSD) research team developed a suite of ultrasound systems that successfully identify and kill cancer cells in live immune T cells in a non-invasive and remote genetic process.
It has been reported that this genetic technique emphasizes how changes in the mechanical characteristics of cellular tissues and physical forces affect gene expression in order to remotely control the activation of genes and cells. The research team disrupted the mechanical characteristics of T cells with ultrasound, and then turned the mechanical signals into genetic control of the cells.
Studies have shown that telemechanical systems can manipulate chimeric antigen receptor recombinant T cells (CAR-T) to target and kill cancer cells, and those manipulated T cells contain electromechanical sensors and genetic converter modules that can The sound waves are activated remotely.
Peter Yingxiao Wang, professor of bioengineering at UCSD, said that CAR-T cell therapy is a paradigm shift in cancer treatment, but it still faces several major challenges, and this study is expected to improve CAR-T cell immunotherapy to unprecedented accuracy and efficiency. At the same time reduce the toxicity caused by off-target.
The research team found that the microbubbles vibrate after contact with the ultrasonic waves, and stimulate the Piezo1 ion channel from the mechanical features to allow calcium ions to enter the cells, thereby initiating calcium activation, deactivating T cell nuclear factor (NFAT) dephosphorylation, and entering the nucleus. NFAT can Combined with the reaction elements of the upstream genetic transformation module, the gene expression of CAR is initiated to complete the identification and killing of cancer cells.
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